Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose rising prevalence places increasing demands on a lengthy diagnostic process. Machine learning (ML) has shown promise in automating ASD diagnosis, but most existing models operate as black boxes and are typically trained on a single dataset, limiting their generalizability. In this study, we introduce a transparent and interpretable ML approach that leverages BioBERT, a state-of-the-art language model, to analyze unstructured clinical text. The model is trained to label descriptions of behaviors and map them to diagnostic criteria, which are then used to assign a final label (ASD or not). We evaluate transfer learning, the ability to transfer knowledge to new data, using two distinct real-world datasets. We trained on datasets sequentially and mixed together and compared the performance of the best models and their ability to transfer to new data. We also created a black-box approach and repeated this transfer process for comparison. Our transparent model demonstrated robust performance, with the mixed-data training strategy yielding the best results (97 % sensitivity, 98 % specificity). Sequential training across datasets led to a slight drop in performance, highlighting the importance of training data order. The black-box model performed worse (90 % sensitivity, 96 % specificity) when trained sequentially or with mixed data. Overall, our transparent approach outperformed the black-box approach. Mixing datasets during training resulted in slightly better performance and should be the preferred approach when practically possible. This work paves the way for more trustworthy, generalizable, and clinically actionable AI tools in neurodevelopmental diagnostics.

ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN) model, incorporating Chebyshev Spectral Graph Convolution and Graph Attention Networks (GAT), to increase the classification accuracy of ASD utilizing multimodal neuroimaging and phenotypic data. Leveraging the ABIDE I dataset, which contains resting-state functional MRI (rs-fMRI), structural MRI (sMRI), and phenotypic variables from 870 patients, the model leverages a multi-branch architecture that processes each modality individually before merging them via concatenation. Graph structure is encoded using site-based similarity to generate a population graph, which helps in understanding relationship connections across individuals. Chebyshev polynomial filters provide localized spectral learning with lower computational complexity, whereas GAT layers increase node representations by attention-weighted aggregation of surrounding information. The proposed model is trained using stratified five-fold cross-validation with a total input dimension of 5,206 features per individual. Extensive trials demonstrate the enhanced model's superiority, achieving a test accuracy of 74.82\% and an AUC of 0.82 on the entire dataset, surpassing multiple state-of-the-art baselines, including conventional GCNs, autoencoder-based deep neural networks, and multimodal CNNs.

We argue that such explanations are natural for humans and are used commonly in domains such as health care and criminology.

We argue that such explanations are natural for humans and are used commonly in domains such as health care and criminology.

The automatic detection of gaze targets in autistic children through artificial intelligence can be impactful, especially for those who lack access to a sufficient number of professionals to improve their quality of life. This paper introduces a new, real-world AI application for gaze target detection in autistic children, which predicts a child's point of gaze from an activity image. This task is foundational for building automated systems that can measure joint attention--a core challenge in Autism Spectrum Disorder (ASD). To facilitate the study of this challenging application, we collected the first-ever Autism Gaze Target (AGT) dataset. We further propose a novel Socially A ware Coarse-to-Fine (SACF) gaze detection framework that explicitly leverages the social context of a scene to overcome the class imbalance common in autism datasets--a consequence of autistic children's tendency to show reduced gaze to faces. It utilizes a two-pathway architecture with expert models specialized in social and nonsocial gaze, guided by a context-awareness gate module. The results of our comprehensive experiments demonstrate that our framework achieves new state-of-the-art performance for gaze target detection in this population, significantly outperforming existing methods, especially on the critical minority class of face-directed gaze.

Caregivers of individuals with autism spectrum disorder (ASD) often find the 77-item Autism Treatment Evaluation Checklist (ATEC) burdensome, limiting its use for routine monitoring. This study introduces a generalizable machine learning framework that seeks to shorten assessments while maintaining evaluative accuracy. Using longitudinal ATEC data from 60 autistic children receiving therapy, we applied feature selection and cross-validation techniques to identify the most predictive items across two assessment goals: longitudinal therapy tracking and point-in-time severity estimation. For progress monitoring, the framework identified 16 items (21% of the original questionnaire) that retained strong correlation with total score change and full subdomain coverage. We also generated smaller subsets (1-7 items) for efficient approximations. For point-in-time severity assessment, our model achieved over 80% classification accuracy using just 13 items (17% of the original set). While demonstrated on ATEC, the methodology-based on subset optimization, model interpretability, and statistical rigor-is broadly applicable to other high-dimensional psychometric tools. The resulting framework could potentially enable more accessible, frequent, and scalable assessments and offer a data-driven approach for AI-supported interventions across neurodevelopmental and psychiatric contexts.

Auditory sensory overload affects 50-70% of individuals with Autism Spectrum Disorder (ASD), yet existing approaches, such as mechanistic models (Hodgkin Huxley type, Wilson Cowan, excitation inhibition balance), clinical tools (EEG/MEG, Sensory Profile scales), and ML methods (Neural ODEs, predictive coding), either assume fixed parameters or lack interpretability, missing autism heterogeneity. We present a Scientific Machine Learning approach using Universal Differential Equations (UDEs) to model sensory adaptation dynamics in autism. Our framework combines ordinary differential equations grounded in biophysics with neural networks to capture both mechanistic understanding and individual variability. We demonstrate that UDEs achieve a 90.8% improvement over pure Neural ODEs while using 73.5% fewer parameters. The model successfully recovers physiological parameters within the 2% error and provides a quantitative risk assessment for sensory overload, predicting 17.2% risk for pulse stimuli with specific temporal patterns. This framework establishes foundations for personalized, evidence-based interventions in autism, with direct applications to wearable technology and clinical practice.

Autism Spectrum Disorder significantly influences the communication abilities, learning processes, behavior, and social interactions of individuals. Although early intervention and customized educational strategies are critical to improving outcomes, there is a pivotal gap in understanding and addressing nuanced behavioral patterns and emotional identification in autistic children prior to skill development. This extended research delves into the foundational step of recognizing and mapping these patterns as a prerequisite to improving learning and soft skills. Using a longitudinal approach to monitor emotions and behaviors, this study aims to establish a baseline understanding of the unique needs and challenges faced by autistic students, particularly in the Information Technology domain, where opportunities are markedly limited. Through a detailed analysis of behavioral trends over time, we propose a targeted framework for developing applications and technical aids designed to meet these identified needs. Our research underscores the importance of a sequential and evidence-based intervention approach that prioritizes a deep understanding of each child's behavioral and emotional landscape as the basis for effective skill development. By shifting the focus toward early identification of behavioral patterns, we aim to foster a more inclusive and supportive learning environment that can significantly improve the educational and developmental trajectory of children with ASD.

In open data sets of functional magnetic resonance imaging (fMRI), the heterogeneity of the data is typically attributed to a combination of factors, including differences in scanning procedures, the presence of confounding effects, and population diversities between multiple sites. These factors contribute to the diminished effectiveness of representation learning, which in turn affects the overall efficacy of subsequent classification procedures. To address these limitations, we propose a novel multi-site adversarial learning network (MSalNET) for fMRI-based mental disorder detection. Firstly, a representation learning module is introduced with a node information assembly (NIA) mechanism to better extract features from functional connectivity (FC). Lastly, an adversarial learning network is proposed as a means of balancing the trade-off between individual classification and site regression tasks, with the introduction of a novel loss function. The proposed method was evaluated on two multi-site fMRI datasets, i.e., Autism Brain Imaging Data Exchange (ABIDE) and ADHD-200. The results indicate that the proposed method achieves a better performance than other related algorithms with the accuracy of 75.56 1.89 % and 68.92 5.40 % in ABIDE and ADHD-200 datasets, respectively. Furthermore, the result of the site regression indicates that the proposed method reduces site variability from a data-driven perspective. The most discriminative brain regions revealed by NIA are consistent with statistical findings, uncovering the "black box" of deep learning to a certain extent. MSalNET offers a novel perspective on the detection of multi-site fMRI metal disorders, specifically in the context of site regression against disease detection. Moreover, it considers the interpretability of the model, which is a crucial aspect in deep learning. Keywords: Multi-site, Functional Connectivity, Adversarial Learning, Interpretability 1 Introduction In recent decades, advances in neuroscience have significantly increased the application of non-invasive neuroimaging techniques for investigating brain functions.

Communication challenges between autistic and neurotypical individuals stem from a mutual lack of understanding of each other's distinct, and often contrasting, communication styles. Yet, autistic individuals are expected to adapt to neurotypical norms, making interactions inauthentic and mentally exhausting for them. To help redress this imbalance, we build NeuroBridge, an online platform that utilizes large language models (LLMs) to simulate: (a) an AI character that is direct and literal, a style common among many autistic individuals, and (b) four cross-neurotype communication scenarios in a feedback-driven conversation between this character and a neurotypical user. Through NeuroBridge, neurotypical individuals gain a firsthand look at autistic communication, and reflect on their role in shaping cross-neurotype interactions. In a user study with 12 neurotypical participants, we find that NeuroBridge improved their understanding of how autistic people may interpret language differently, with all describing autism as a social difference that "needs understanding by others" after completing the simulation. Participants valued its personalized, interactive format and described AI-generated feedback as "constructive", "logical" and "non-judgmental". Most perceived the portrayal of autism in the simulation as accurate, suggesting that users may readily accept AI-generated (mis)representations of disabilities. To conclude, we discuss design implications for disability representation in AI, the need for making NeuroBridge more personalized, and LLMs' limitations in modeling complex social scenarios.